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I just bought a pair of SRAM Powerlocks for 10-speed chains. The packaging says that they can only be used with SRAM chains. Will anything nasty happen if I use it with a Shimano chain and cassette?

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Try to imagine all life as you know it stopping instantaneously and every molecule in your body exploding at the speed of light. (Since that's the worst-case scenario just try it and see what happens.) –  Daniel R Hicks Sep 7 '13 at 15:45

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They will work fine together- same if you swap the brands around. I've done this many times for myself and for others with no issue and it's common practice amongst bike shops. This is strictly marketing & legal covering of their own asses. If you look at Wippermann Connex Link compatibility they say that the one link is compatible with SRAM, Shimano, and Campy. They're all so close in terms of the spacing that interchanging their quick links doesn't make a difference.

As an aside, those Wippermann Connex quick links rock. Tool free installation and removal, and it's almost impossible for them to come undone while riding.

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According to what I'm reading, that should be no problem. Link provided.

http://www.amazon.com/Sram-P-Lock-10-Speed-Bicycle-Chain/product-reviews/B003VFEF6Q

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