The short answer is no. Now for the long answer...
Mountain bike and road bike wheels are different diameters and use tires that are different diameters. Specifically, mountain bikes use 26" tires and road tires use the ridiculously meaningless 700c sizing. I won't get into what these sizes mean here, but you can find more info on this site or, if you really want to dork out for a bit, read Sheldon Brown's page on tire sizing.
As Batman mentioned, you can purchase slicks and semi-slicks for 26" rims. They're not technically "road" tires - they're a bit wider and run lower pressures - but they still reduce rolling resistance. There are lots of options. Just shop around
All that said, I'm not sure what you find uncomfortable about your mountain bike tires. Mountain bike tires are typically more comfortable than road bike tires. One thing you may consider is simply lowering the pressure in your tires. The maximum pressure listed on the side is very often much higher than you want or need. You can read more about finding the correct pressure here.