The primary consideration in finding a saddle is how well it suits your sit bone shape and groin tissue. Some people do best with saddles that have massive cutouts (heck, even those ones that look U shaped because the nose is split too), while others can use Fiziks or the like that are rounded without any cutout whatsoever.

Cutouts can be disadvantageous as they can increase the pressure placed on your backside (same force but smaller area). However, if cutout saddles are what suits your physiology best, you're actually going to harm yourself more by riding an uncomfortable non-cutout saddle.

The primary consideration in finding a saddle is how well it suits your sit bone shape and groin tissue. Some people do best with saddles that have massive cutouts (heck, even those ones that look U shaped because the nose is split too), while others can use Fiziks or the like that are rounded without any cutout whatsoever.

Cutouts can be disadvantageous as they can increase the pressure placed on your backside (same force but smaller area; imagine how a saddle with a massive cutout resembles a cookie cutter). However, if cutout saddles are what suits your physiology best, you're actually going to harm yourself more by riding an uncomfortable non-cutout saddle.