I have a Sunrace m2t derailleur on an old Batavus holiday dutch bike and I am running the gear cable from the derailleur down the chain stay under the bb and up the down tube. The bend on the gear cable from the derailleur isn't too extreme, but it made me think about if there is a limit before shifting or long term reliability is affected.
I have added images below showing the current setup (UPDATE: and after). The issue is, because it is a step through bike, the alternative to running the cable along the chainstay is going up the seat stay and then down the seat tube, then back along the down tube.
Interestingly looking at http://www.killasgarage.bike/uncategorized/cable-routing-experimental-results/ perhaps shortening or repositioning the cable to minimum the distance out and then in might help, so I've done that and learnt something new (added photo)!