Of course any seat needs to be adjusted to the proper height, fore and aft position, saddle tilt, and in conjunction with your foot/pedal positioning.
More "cushioning" isn't always the answer. I used to have the soft seat and then add a gel cushion to that. This made the seat wider, but it still became uncomfortable after about 30 to 40 miles. It was just too wide.
I switched to a Brooks leather saddle, the B-17 model, and after treating the saddle with their Proofhide, and a break in period of about 750 miles or so, the saddle seemed to be more comfortable than a "softer" saddle, mostly because of the width being a bit narrower.
I found that adding a pair of Zoic padded shorts or wearing padded touring shorts in good weather, was the perfect combination for me. I'm 5' 11" and weigh about 200 pounds. Sometimes it's just necessary to try different combinations of soft/firm and regular, wide or narrow widths of saddle to get the combination that works for you. This also includes saddles that have the "cutout" area in the seat for your Perineum area.