My bike is Giant Defy 5 and trainer is Elite Rampa. I notice that after putting my bike on the trainer and riding for a while, the rear wheel tilts to one side, usually resulting in the wheel rubs the brake and even frame. I do not have this problem outside. Is there something wrong with my trainer setup? Thanks a lot for your help!
I can't think of any reason that would be migrating in the frame unless it wasn't secured enough to begin with. You should check the tightness of your quick release.