Preface: for about 15 years I have used always the same pair of gloves, which worked as a charm. Since they started to show their age and that version is since long time no longer produced, I looked for another pair.
I tried one, which had a padding in the palm, and they felt comfortable on my hands. Only after wearing them a few hours on the ride I noticed the padding, pushing on my palms, made my hands numb, so I had no other choice than not wearing them.
Is there a way to assess gloves comfort in the few minutes one can try them in a shop?