At those weights you're looking at three wheels minimum and maybe four.
Simply loading 1000 pounds (500 kg) onto a trailer will be difficult without a lifter of some sort, and you would have to balance it perfectly over the axle. On a car trailer, nose weight can be several hundred kilos acceptably, but on your bike any more than 2-5 kilos could see the whole thing rotate on the axle while loading.
Three wheels with a super-low slung platform would be safer.
You'll also require power brakes because 500 kilos is a LOT of weight. I've ridden with 100 kilos on a trailer and it was really too much - had problems getting moving, and it was hard to get over intersections from stopped.
A 2 degree upslope in the road to go over a railway crossing damn-near stopped me cold, and the similar downslope on the other side was a surprise too.
Also check with your local road rules about what constitutes a maximum size and weight for a bicycle. Could be the dimensions you're planning make the bike too big and could be classed as something else.
Don't be a danger to yourself and other road users - this project sounds dangerous. I'm all for bikes in life, but look to hire movers or use a car trailer for this one.
bikecalculator.com says that a 500 kilo bike with a 75 kilo rider doing 150 watts on the flat will achieve around 15 km/h (9 mph) Same combo with a bike of 10 kilos is 28 km/h
I haven't got a good calculation for stopping time for those masses from those velocities, but 5 times the weight will take a minimum of 5 times as long and your stopping distance will be much greater, to the point it would be unsafe for you and others to be sharing the roadway.