There are two logical approaches to selecting road bicycle tires for pavement. (I won't consider offroad and winter/ice/snow riding here.)
The first approach is to realize that fixing a flat takes 5-10min, and that any puncture protection in the tire increases rolling resistance so much that every minute of flat-fixing time saved results in hour of additional trip time. This approach suggests that the best possible tire is one with minimal puncture protection and thus minimal rolling resistance. Unfortunately, you can't find tires without puncture protection today, but fortunately, you can find tires with minimal puncture protection. I believe that of the current offerings, Continental Grand Prix 5000 is the best tire. Pick either 28mm or 32mm size. The 23mm and 25mm require so high pressures that you may have difficulty obtaining those pressures with an easy-to-carry mini pump, so don't select those. Also, the 23mm and 25mm will have higher rolling resistance on anything but completely smooth pavement, and the high pressures will be very uncomfortable.
The second approach is for those who can't fix flats or for some reason hate fixing flats. For those, the best vehicle may very well be a car instead of a bike, but let's assume that you hate fixing flats but love riding bike. This approach is to maximize the puncture protection, and thus, equivalently, maximize the rolling resistance. I believe that Schwalbe Marathon Plus is one of the best tires for this approach. Pick the widest tire that fits your frame with enough clearance. The wider the tire, the more room there is for rubber, and the better the puncture protection will be.
Don't select any tire between these two extremes! In particular, GatorSkins were suggested in a comment. Do not select GatorSkin as your tire! I have used Continental GatorSkins, and found that they have too much rolling resistance and still aren't protected from punctures well enough -- I have had numerous flats with GatorSkins. If puncture protection is what you're looking for, go for a true puncture-protected tire such as Schwalbe Marathon Plus. If low rolling resistance is what you're looking for, select a tire optimized for that such as GP 5000.