I've been thinking about the way the body is positioned on a recumbent bicycle and it seems like knee pain might result. Even if you use a low gearing I think the force direction will always be in a direction on your knees differently from an upright bicycle...
I googled bentrideronline knee pain from recumbent riding and there were tons of results. That seems to be very surprising since recumbent riding is such a small sample of bicycles. Some people were even reporting never having knee pain and then getting knee pain when switching to a recumbent.
I was thinking a recumbent would be the ultimate in comfort but I'm thinking some sort of different geometry upright frame bicycle would be the best between comfort and not getting knee pain.