This is not a problem at all.
I bought a Sigma BC 14.16 STS cyclocomputer some time ago.
The last recorded statistics from this computer are: 4314 kilometers, 45169 meters climbed.
This means that in the areas where I ride (nearest mountains thousands of kilometers away), 10.5 meters is climbed per kilometer.
Your 1500 meters, 65 km would be 23.1 meters climbed per kilometer.
I know a person of normal weight and good fitness can easily go and ride 100 km in the non-mountainous region where I live. I have done it. So, 1050 meters climbed per day is easy.
Your 1500 meters wouldn't be far above that 1050 meters.
I don't think 1500 meters would be a problem for one day. However, if your average of 1500 meters per day actually consist of 50% days with 0 meter climb and 50% days with 3000 meter climb, and if that 3000 meter climb would be one continuous climb, then maybe it could be too much.
Also, a good idea is to consider the energy effort needed. 15 kg bike, 10 kg cargo, 70 kg rider is 95 kg. 1500 meters climbed is 9.81 * 1500 * 95 J = 1.4 MJ = 334 kcal
, but this is not food energy. Food energy is converted to mechanical energy at 25% efficiency so it's actually 5.6 MJ = 1335 kcal
(plus air resistance and rolling resistance which I didn't consider here, so the actual number is larger, I suspect around 1900 kcal as food energy).
My daily commute with my electric bike takes about 0.7 MJ = 170 kcal
, but as food energy it's 2.8 MJ = 617 kcal
. I do have lunch while at work, but I have ridden 60 km distances without eating inbetween, and that 60 km would be actually about 1.0 MJ = 235 kcal
, and as food energy 3.9 MJ = 939 kcal
.
And that 100 km with a non-e-bike I have done is about 2 MJ = 487 kcal
and as food energy 8.2 MJ = 1950 kcal
. A normal human can do that.
I think that a 1500 meter daily climb requires the possibility to eat midway. Don't plan to climb 1500 meters with no possibility of eating. If it's far away from restaurants, carry enough food with you, plus possibly the means to cook the food if it needs cooking.