I ride a Cannondale Topstone outside during the warmer months and then on a Wahoo Kickr when it gets cold. When I put the bike on the trainer I get a grinding noise and vibration when in some gears. It's not a crunchy grinding as if there's some debris in a bearing, but rather it feels as though the chain isn't riding over the rear sprockets evenly. I have identical clusters on both the bike wheel and the trainer. I will say that the wheel cluster has many more miles and harder miles on it. New chain last spring with only about 800 or 900 miles on it. This is a through axle setup, so it isn't an alignment issue, I don't think. Many gears are just fine, but the middle section gives the vibration.
I had it at a shop and they were unable to resolve the issue.